Stendra Vs. Levitra

More than 30 million men in the U.S. are affected by erectile dysfunction (ED). Current ED drugs on the market include Pfizer Inc.’s Viagra, Eli Lilly’s Cialis and GlaxoSmithKline and Bayer’s drug Levitra.

Now a new drug is on the market. Stendra™ made by Vivus, Inc.; Mountain View, California. Approved by the US Food and Drug Administration Stendra (avanafil) is a novel second-generation PDE5 inhibitor. How will it compare with the other agents previously on the market in terms of efficacy, time to onset, and side effects?

Avanafil, a PDE5 inhibitor, reaches peak plasma concentration in 35 minutes and has a terminal elimination half-life of 3-5 hours. This pharmacokinetic profile confers a rapid onset of action with success reported in 67%-72% of intercourse attempts within 15 minutes of administration. Concomitant food intake does not affect the absorption of avanafil compared with sildenafil and vardenafil. Drug metabolism occurs in the liver, and bile is the main route of excretion for avanafil and its metabolites. Cytochrome P450 is responsible for metabolizing the drug. Studies have shown that once- or twice-daily dosing of avanafil does not cause significant drug accumulation in the body.

Stendra Levitra
Onset of action 15-30 minutes 60-120 minutes
Plasma half-life 3 hours 17.5 hours
Duration of action Up to 6 hours Up to 36 hours
Effect of food intake Not affected Not affected
Unique side effects  None Back pain, myalgias

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